Absorption Rapid.
Distribution Vd is 3 L/kg. Protein binding is approximately 60% (parent); 1,2 dinitroglycerin, 60%; 1,3 dinitroglycerin, 30%.
Metabolism Primarily metabolized in the liver by nitrate reductase; known sites of extrahepatic metabolism include red blood cells and vascular walls. Metabolized to inorganic nitrate and the active 1,2 and 1,3 dinitroglycerols.
Elimination Serum t ½ is 3 min and 1 to 8 min (sublingual). Cl is 1 L/kg/min.
Onset 1 to 2 min (IV), 1 to 3 min (sublingual), 1 h (extended-release).
Peak 1 to 4 h (immediate-release tablet), 6 to 7 min (sublingual), 2 h (transdermal).
Duration 3 to 5 min (IV), 30 to 60 min (sublingual), 5 h (extended-release), up to 12 h (topical ointment).
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