Acetaminophen, cyclosporine, ethanol, levodopa, tetracycline
Metoclopramide may increase oral bioavailability or absorption of these drugs.
Anticholinergic, opioid analgesics, levodopa
May decrease effect of metoclopramide on gastric emptying.
Cefprozil, cimetidine, digoxin
Metoclopramide may decrease oral absorption of these drugs.
CNS depressants (eg, alcohol, anesthetics, barbiturates, opiates)
May potentiate CNS depressant effects of metoclopramide.
Succinylcholine and possibly mivacurium
By inhibiting plasma cholinesterase metoclopramide may prolong neuromuscular blocking effects such as respiratory depression and paralysis.