Alpha-adrenergic blockers (eg, phentolamine) Vasoconstricting and hypertensive effects are antagonized.
Antihistamines Epinephrine effects may be potentiated.
Beta-blocking agents May decrease effects of these agents, resulting in hypertension.
Diuretics Vascular response may be decreased.
Ergot alkaloids, phenothiazines, nitrates Pressor effects of epinephrine may be reversed.
Furazolidone, methyldopa, Rauwolfia alkaloids May cause hypertension.
General anesthetics (eg, halothane, cyclopropane), cardiac glycosides The potential for the myocardium to be sensitized to the effects of sympathomimetic amines is increased. Arrhythmias may result with coadministration and may respond to beta-blockers.
Guanethidine May increase pressor response.
Levothyroxine Epinephrine effects may be potentiated.
Oxytoxic drugs May cause severe persistent hypertension.
Tricyclic antidepressants May potentiate epinephrine's vasopressive effects.
Incompatibility Epinephrine is unstable in alkaline solutions (eg, sodium bicarbonate); avoid admixture.
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