[2-(diphenylmethoxy)ethyl]dimethylamine

Absorption
T max is 1 to 4 h (oral).

Distribution
Widely distributed, including the CNS. Excreted in breast milk. 98% to 99% protein bound.

Metabolism
Metabolized in the liver.

Elimination
A portion of the drug excreted unchanged in the urine. The t ½ is 1 to 4 h.

Onset
Rapid onset (IV or IM).

Duration
6 to 8 h.

Alcohol, CNS depressants
May cause additive CNS depression.

Beta-blockers metabolized by CYP2D6 enzyme (eg, metoprolol)
Plasma levels may be elevated by diphenhydramine, increasing CV effects.

MAOIs
May increase anticholinergic effects.

Incompatibility
Injectable form is incompatible with dexamethasone sodium phosphate, furosemide, iodipamide meglumine, parenteral barbiturates, and phenytoin.