2-[(3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl) methylsulfinyl] -1H-benzoimidazole

本品應於餐前服用，成人每天1次，口服lansoprazole 15mg。治療胃潰瘍和逆流性食炎通常須連續服用8週，治療十二指腸潰瘍須連續服用4週。
本品不應嚼食。請將藥錠製其舌上待其分解，可喝水或不喝水，直到顆粒可以吞服。通常藥錠不到一分鐘便會溶解。 

Absorption：Absorption is rapid. T max is approximately 1.7 h. C max and AUC are approximately proportional in doses from 15 to 60 mg single dose administration. Absolute bioavailability is over 80%. C max and AUC decrease 50% if given 30 min after food.

Distribution：Protein binding (97%) is constant over the concentration range of 0.05 to 5 mcg/mL.

Metabolism：Extensively metabolized in the liver. Metabolites are hydroxylated sulfonyl and sulfone derivatives (very little activity).

Elimination：Significant biliary excretion of the metabolites. Mean t ½ is 1.9 to 2.9 h.

Special Populations：
Hepatic Function Impairment：
Mean t ½ prolonged to 3.2 to 7.2 h and AUC increased up to 500%; dose reduction is recommended in severe hepatic disease.

Elderly：Cl is decreased with t ½ increasing approximately 50% to 100%. Because mean t ½ remains between 1.9 to 2.9 h, repeated once daily dosing does not accumulate; no adjustment needed.

胸痛、便秘、腹瀉、噁心、頭痛。

Digoxin
Increased digoxin absorption, leading to elevated levels and increased risk of toxicity may occur.

Ketoconazole
Effects may be decreased by lansoprazole.

Sucralfate
May delay and reduce absorption; give lansoprazole at least 30 min before sucralfate.