Anesthetics Depression of cardiac contractility, conductivity, and automaticity as well as vascular dilation associated with anesthetics may be potentiated.
Benzodiazepines (eg, midazolam, triazolam), carbamazepine, cyclosporine, digitalis, encainide, lovastatin Plasma levels of these agents may be elevated by diltiazem, increasing the pharmacologic and toxic effects.
Beta-blockers May have additive negative inotropic and chronotropic effects.
Cimetidine, ranitidine Diltiazem levels may be increased.
Other antihypertensive agents May have additive effects.
Rifampin Coadministration lowered diltiazem plasma concentrations to undetectable levels.
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