Alfentanil, alfuzosin, almotriptan, alprazolam, aripiprazole, atorvastatin, bosentan, buspirone, busulfan, carbamazepine, cerivastatin, cilostazol, cinacalcet, conivaptan, cyclophosphamide, cyclosporine, diazepam, digoxin, disopyramide, docetaxel, eletriptan, fentanyl, gefitinib, halofantrine, haloperidol, protease inhibitors, quetiapine, risperidone, sildenafil, sirolimus, tacrolimus, tadalafil, tolterodine, trimetrexate, vardenafil, venlafaxine, warfarin, zolpidem Levels may be elevated by itraconazole, increasing the risk of adverse reactions.
Antacids, carbamazepine, grapefruit juice, H 2 -receptor antagonists (eg, cimetidine), isoniazid, orange juice, phenobarbital, phenytoin, proton pump inhibitors Plasma levels of itraconazole may be decreased.
Calcium blockers (eg, amlodipine, felodipine, nifedipine, verapamil) Edema has occurred with concomitant dihydropyridine calcium blockers.
Cisapride, dofetilide, eplerenone, ergot alkaloids, levacetylmethadol, lovastatin, nisoldapine, oral midazolam, pimozide, quinidine, ranolazine, simvastatin, triazolam Serious CV events may occur. Coadministration is contraindicated.
Corticosteroids (eg, budesonide, dexamethasone, methylprednisolone) The metabolism of these corticosteroids may be inhibited, resulting in increased toxicity.
Didanosine (buffered) May decrease therapeutic effects of itraconazole. Administer itraconazole 2 h or more before didanosine.
HMG-CoA reductase inhibitors Coadministration may increase risk of rhabdomyolysis. Lovastatin and simvastatin coadministration is contraindicated.
Hypoglycemic agents Hypoglycemia may occur. Monitor blood glucose.
Macrolide antibiotics (eg, clarithromycin, erythromycin), protease inhibitors (eg, indinavir, ritonavir) Plasma levels of itraconazole may be increased.
Nevirapine, phenytoin, rifamycins Reduced plasma levels of itraconazole may occur. Avoid use if possible.
Phenytoin, rifamycins, vinca alkaloids Levels may be elevated by itraconazole, increasing the risk of adverse reactions. Avoid use if possible.
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