Absorption Intranasal About 34% reaches systemic circulation. T max is about 0.7 h.
Distribution Vd is 2 to 3 L/kg (or 200 L). Budesonide is 85% to 90% protein bound.
Metabolism Liver Rapidly metabolized; CYP3A4 is involved in the formation of 2 metabolites (less than 1% of budesonide activity).
Elimination The t ½ is 2 to 3 h. Budesonide is excreted in the urine (about 60%) and feces as metabolites; no unchanged drug is detected in the urine.
Special Populations Children Plasma concentrations are approximately twice those of adults.
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