µ²ºc¦¡ |
|
Nicardipine 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
|
UpToDate |
UpToDate ³sµ²
|
ÃIJz§@¥Î |
|
Nicardipine HCl Âǥѧí¨î¶tÂ÷¤l¶i¤J¦åºÞ¥·Æ¦Ù²ÓM¤ºªº¤è¦¡¨Ó²£¥Í¦åºÞªºµÎ±i§@¥Î¡CNicardipine HCl ¹ï©ó¦åºÞ¥·Æ¦Ùªº¿ï¾Ü©Ê¬O¤ß¦Ùªº30,000 ¿¡A©Ò¥H¹ï¦åºÞªº¿ï¾Ü©Ê°ª©ó¨ä¥Lªº¶tÂ÷¤l«ú§Ü¾¯(Nifedipine, Verapamil, Diltiazem)¡C
|
¾AÀ³¯g |
|
¾A¥Î©ó·í¤fªAªvÀø¤£¥i¦æ©Î¤£¦X¾A®É¡A¹ï°ª¦åÀ£ªºµu´Á³B¸m¡C
|
¥Îªk¥Î¶q |
|
¦¨¤H¤§°_©l¾¯¶q¡G 3-5mg/h «ùÄò¿éª`15¤ÀÄÁ¡A¾¯¶q¥i¥H0.5©Î1mg¨C15¤ÀÄÁ¤§¿éª`³t²v³vº¥½Õ°ª¡A¦ý³Ì¤j¤£¶W¹L15mg/h¡Fºû«ù¾¯¶q¡G¹F¨ìªvÀø¥Ø¼Ð®É¡AÀ³½wºC°§C¾¯¶q¡A³q±`¥H2-4mg/hºû«ùªvÀø®ÄªG¡C ƒÜ ¦Ñ¦~/¥¥°ü/¨xµÇ¥\¯à¤£¨}ªÌ¡G ¨Ì¾Ú¯f¤H¦åÀ£¤ÎÁ{§É±¡ªp¡A°_©l¾¯¶q¬°1-5mg/h¡A«ùÄò¿éª`30¤ÀÄÁ«á¡Aµø¹ê»ÚªvÀø®ÄªG¡A¾¯¶q¥i¥H0.5mg/h ³vº¥½Õ°ª©Î°§C¡A¦ý³Ì¤j¤£¶W¹L15mg/h¡C ƒÜ ¤p¨à¡G ¹ï¦²£¨à¡B·s¥Í¨à¡B¨Å¥®¨à¡B¤p¨à¤Î¨àµ£¤§¦w¥þ©Ê¤Î¦³®Ä©Ê©|¥¼½T¥ß¡C¥»ÃĤ§ÀR¯ß¿éª`À³¶È¨Ï¥Î©ó¤p¨à±wªÌ©ó«¯g¥[Å@©Î¤â³N«á¦M«æ¥Í©R¤§°ª¦åÀ£¡C °_©l¾¯¶q¡G ¦b¦M«æ±¡ªp ¤U¡A«Øij°_©l¾¯¶q¬° 0.5-5 mcg/kg/min¡C«Øijºû«ù¾¯¶q¡G1-4 mcg / kg /min¡C ¥»ÃÄÀR¯ß¿éª`¨Ï¥Î©óµÇ¥\¯à¤£¨}¤p¨àÀ³ÂÔ·V¤p¤ß¡A¥BÀ³¨Ï¥Î³Ì§C¾¯¶q¡C ¤â³N®É²§±`°ª¦åÀ£ªººò«æ³B¸m ¥»ÃÄ«Y¥H¥Í²z¹ÆQ²G©Î5%¸²µå¿}ª`®g²Gµ}ÄÀ¦¨ Nicardipineªº 0.01~0.02% (1 mL¬Û·í©ó 0.1~0.2 mg)·»²G¡A§@ÀR¯ß¿éª`¡C°_ªì¡A¥H¨C¤ÀÄÁ¡B¨C¤½¤çÅ髬۷í©ó2~10 mcgªº¿éª`³t²v(2~10 mcg/kg/min)§ë»P¡A¨Ï¦åÀ£¤U°¦Ü´Á±æÈ¡AµM«á¦A¨Ì¦åÀ£°»´ú¨Ó½Õ¸`¿éª`³t²v¡AY¦³¨Ï¦åÀ£«æ³t¤U°ªº¥²n®É¡A«hª½±µ¨Ï¥Î¥»ÃÄ¡A¥H¨C¤½¤çÅ髬۷í©ó Nicardipine 10~30 mcg(10~30 mcg/kg)¤§¾¯¶q¡A§@ÀR¯ß¤º§ë»P¡C °ª¦åÀ£©Êºò«æ¯g ¥»ÃÄ«Y¥H¥Í²z¹ÆQ²G©Î 5%¸²µå¿}ª`®g²Gµ}ÄÀ¦¨ Nicardipineªº 0.01~0.02% (1 mL¬Û·í©ó 0.1~0.2 mg)·»²G¡A§@ÀR¯ß¿éª`¡C¦¹®É¡A¥H¨C¤ÀÄÁ¡B¨C¤½¤çÅé «¬Û·í©ó 0.5~6 mcgªº¿éª`³t²v§ë»P¡A°_ªì¡A¥H¨C¤ÀÄÁ¨C¤½¤çÅé« 0.5 mcg ªº¿éª`³t²v(0.5 mcg/kg/min)§ë»P¡A¨Ï¦åÀ£¤U°¦Ü´Á±æÈ¡AµM«á¦A¨Ì¦åÀ£°»´ú¨Ó½Õ¸`¿éª`³t²v¡C
|
ÃİʤO¾Ç |
|
§¿²G¤¤¥Dnªº¥NÁª« °·±d¦¨¤H§¿²G¤¤¥Dnªº¥NÁª«¬°M11 ªº¦@³mª«(³oÓ¥NÁª«¥Dn¨Ó¦Û©óN-benzyl-Nmethylamino group ªº°¸Ñ¡AÁÙ¦³pyridine Àôªº®ñ¤Æ) ¡A¦b¤HÅ饻ÃÄ¥Dn¥ÑCYP3A4¨Ó¥NÁ¡C ¦å¼ß³J¥Õªºµ²¦X²v ¦bÅé¥~(°·±d¦¨¤H)¡BÅé¥~(«æ©Ê¤ßŦ°IºÜ¯f±w)¤ÎÅ餺(¥þ¨³Â¾K¤¤¯f±w)ªº¦å¼ß³J¥Õµ²¦X²v§¡¬°90%¥H¤W¡C
|
°Æ§@¥Î |
|
°¸º¸¦³äú¤ß¡A¹Ã¦R¡A¤ß±ª¡AÀYµh¡C
|
¥æ¤¬§@¥Î |
|
¥»ÃÄ¥Dn¥Ñ¨xŦCYP3A4¨Ó¥NÁ¡C ¸Ô²Ó¤º®e¸Ô¥ó¥é³æ¡C
|
¸T§Ò |
|
(1) ¹ï¥»ÃÄ©Î¥ô¦ó½á§Î¾¯¹L±Óªº±wªÌ¡C (2) ÄY«¥D°Ê¯ßä¯U¯¶ªº±wªÌ¡C (3) «æ©Ê¤ß¦Ù±ð¶ë«á¯fªpÄY«¥B¤£Ã©wªÌ¡C
|
ª`·N¨Æ¶µ |
|
(1) ¹ï©ó°ª¦åÀ£©Êºò«æ¯g±wªÌ¡A¦pªG¹F¨ì´Á±æªº¦åÀ£«á¤´¶·±±¨î¦åÀ£¡A¦Ó¥B¤fªAµ¹ÃÄ¥i ¦æ¡A«hÀ³§ï¥Î¤fªAÃĪ«¡C (2) ¹ï©ó°ª¦åÀ£©Êºò«æ¯g±wªÌ¡A´¿¦³³ø¾É«ü¥X¡A°±¥Î¥»ÃÄ«á¦åÀ£¥i¯à·|¦A«×¤É°ª¡C¦]¦¹¡A¥»ÃÄÀ³¥H³v¨B´î¤Ö¾¯¶qªº¤è¦¡°±ÃÄ¡A°±¥Î¥»ÃÄ«áÀ³ÂÔ·V±±¨î¦åÀ£¡C§ï¬°¤fªAªvÀø«á¡AÀ³¯d·N¦åÀ£¥i¯à·|¤É°ª¡C
|
ĵ»y |
|
¹ï©ó¸£¥X¦å«æ©Ê´Á©M¦]¸£¤¤·«æ©Ê´Á¦ÓÆ`¤ºÀ£¤®¶iªº±wªÌ¡A¨Ï¥Î¥»ÃÄÀ³¸Ón¤p¤ßÆ[¹î±wªÌªº±¡ªp¡A¨Ò¦p¦åÀ£¡C¦¹Ãþ±wªÌÀ³¸Ó©ó¨ã¦³ºò«æ«æ±Ï³]³ÆªºÂåÀø°| ©Ò¤º®Ú¾Ú³Ì·s«ü«nªvÀø¡C
|
ÃÄ«~«O¦s¤è¦¡ |
|
½Ð±K«ÊÀx¦s©ó 25¢J¥H¤U¡A¤ð¶·¦B¦s¨ÃÁקK¶§¥úª½®g¡C
|