Absorption Topical steroids can be absorbed from intact skin. Occlusive dressings, inflammation, and other disease processes in the skin increase percutaneous absorption of topical steroids.
Distribution Once absorbed, corticosteroids are variably bound to plasma protein.
Metabolism Corticosteroids are metabolized primarily in the liver.
Elimination Corticosteroids are excreted primarily by the kidneys and to varying amounts into the bile.
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