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Absorption
Extended-Release (375 to 500 mg with food)
C max is 3.7 to 8.2 mcg/mL, T max is 2.5 to 2.7 h, AUC is 9.9 to 18.1 mcg•h/mL.
Immediate-Release (500 mg without food)
C max is 16.8 mcg/mL, T max is 0.9 h, AUC is 19.2 mcg•h/mL.
Food
The AUC and C max are greater when the extended-release tablets are taken with food. The C max is decreased when the immediate-release capsules are taken with food.
Distribution
Cefaclor is 25% protein bound.
Metabolism
No evidence of metabolism.
Elimination
Plasma t ½ is about 1 h. About 60% to 85% is excreted unchanged in the urine within 8 h.
Special Populations
Renal Function Impairment
The t ½ is slightly prolonged. In those with complete absence of renal function, t ½ is 2.3 to 2.8 h.
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