Triprolidine：2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridine

Pseudoephedrine：(1S,2S)-2-methylamino-1-phenylpropan-1-ol

Pseudoephedrine為擬交感神經興奮劑，其血管縮作用可使鼻腔、支氣管黏膜之腫脹消失，減少充血和水腫現象。

Triprolidine為長效性抗組織胺劑，作用持續時間可達12小時。其兼具擬副交感神經遮斷作用而減輕鼻溢，對於過敏性鼻炎、竇炎等可緩解過敏現象。

Triprolidine
Elimination
Plasma t ½ is about 3 to 3.3 h.

Pseudoephedrine
Distribution
Distributes into breast milk.

Metabolism
Partially metabolized in the liver.

Elimination
Renal (55% to 75% as unchanged); acidic urine accelerates rate of excretion.

Onset
15 to 30 min.

Peak
30 to 60 min.

Duration
3 to 4 h; 8 to 12 h (extended-release).

Triprolidine
Alcohol, CNS depressants (eg, narcotics, sedatives)
Additive CNS depression possible.

MAOIs
Anticholinergic effects may increase.

Pseudoephedrine
Furazolidone, guanethidine, methyldopa
Increased BP.

MAOIs
Severe headache, hypertension and hyperpyrexia; can cause hypertensive crisis.

Urinary acidifiers (eg, ammonium chloride)
Increased elimination of pseudoephedrine.

Urinary alkalinizers (eg, sodium bicarbonate)
Decreased elimination of pseudoephedrine.

1.避免在睡前2小時以內服用。

2.勿與OTC藥物併用，因很多含有Ephedrine或其他類交感神經作用或其他抗組織胺類藥物，會強化本品的作用。

3.若有非常不安或過敏徵兆時應禁斷藥物。