4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one

Absorption
When administered in sesame oil, it results in the slow and sustained release of haloperidol. T max is 6 days after injection. Steady-state plasma concentrations are achieved after the third or fourth dose.

Distribution
The relationship between dose of haloperidol decanoate and plasma haloperidol concentration is roughly linear for doses below 450 mg.

Elimination
Apparent t ½ is approximately 3 wk for the decanoate and 18 h for oral.

副作用可見不眠、焦躁、抑鬱及自主神經症狀，又易伴隨強烈椎體外路症狀，應加注意。

Anesthetics, opiates, alcohol
May increase CNS depressant effects.

Anticholinergics
May increase anticholinergic effects. May worsen schizophrenic symptoms, decrease haloperidol serum concentrations, and lead to tardive dyskinesia.

Azole antifungal agents (eg, itraconazole)
Plasma levels of haloperidol may be elevated, increasing the risk of side effects.

Carbamazepine
May decrease effects of haloperidol.

Lithium
May induce disorientation, unconsciousness, and extrapyramidal symptoms.

Rifamycins (eg, rifampin)
Plasma levels of haloperidol may be reduced, decreasing the clinical effectiveness.