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Amiodarone
Profound bradycardia, sinus arrest, and hypotension may occur.
Anesthesia (conduction, peridural, spinal)
When used with fentanyl, management of respiration may be complicated.
Diazepam
May produce CV depression when given with high doses of fentanyl.
Droperidol
May cause hypotension and decrease pulmonary arterial pressure.
MAOIs
Fentanyl not recommended for use in patients who have received MAOIs within 14 days.
Neuroleptics
Risk of hypertension may be increased. In addition, ECG monitoring is indicated.
Nitrous oxide
Nitrous oxide may cause CV depression with high-dose fentanyl.
Potent CYP3A4 inhibitors (eg, clarithromycin, diltiazem, erythromycin, ketoconazole, itraconazole, nefazodone, protease inhibitors [eg, ritonavir]), other CNS depressants (eg, alcohol, barbiturates, benzodiazepines, general anesthetics, other opioids, phenothiazines, sedating antihistamines, sedatives/hypnotics, skeletal muscle relaxants, tranquilizers)
Increased depressant effects; hypoventilation, hypotension, profound sedation, and life-threatening respiratory depression may occur.
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