| 結構式 |
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2-(Cyclohexylcarbonyl) -1,2,3,6,7,11b-hexahydro-4H-pyrazino (2,1-alpha) isoquinolin-4-one
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| UpToDate |
UpToDate 連結
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| 藥理作用 |
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本品為吸蟲驅除劑。它與吸蟲外皮膜磷脂質相互作用使蟲之膜構造成不安定化，促進Ca++往吸蟲之流入，已流入吸蟲體內之Ca++，使吸蟲之肌肉收縮，並造成吸蟲外皮構造之損傷(空胞化等)。
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| 適應症 |
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由血吸蟲屬感染引起的病症：埃及血吸蟲、日本血吸蟲、中華肝吸蟲、肺吸蟲。
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| 用法用量 |
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1次20mg/kg，1天2次，服用2天。日本吸蟲症：1天1∼2次，服用1天。
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| 藥動力學 |
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Absorption
Rapidly absorbed (80%). T max is 1 to 3 h.
Distribution
CSF levels are 14% to 20% of plasma concentration. Appears in breast milk. Protein binding is 80% to 85%.
Metabolism
Extensive first-pass metabolism, rapidly metabolized to inactive mono- and polyhydroxylated derivatives.
Elimination
Urine (as metabolites), small amounts in feces. Serum t ½ is 0.8 to 1.5 h.
Special Populations
Hepatic Function Impairment
Moderate to severe; plasma concentration were significantly elevated in one study.
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| 副作用 |
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1. 肝：肝檢查值異常。
2. 血液：紅血球、血小板減少，嗜酸性血球增多，白血球增加。
3. 噁心、嘔吐，間有腹痛。
4. 頭痛、頭重感、間有思眠、眩暈。
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| 交互作用 |
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Cimetidine
Plasma levels of praziquantel may be elevated, increasing the pharmacologic and adverse effects.
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| 禁忌 |
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對本藥成份過敏者
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| 注意事項 |
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1.有釣條蟲症患者，禁用本品。 2.治療2個月後檢定病患的寄生蟲是否完全根除。
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| 藥品保存方式 |
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藥品應置於攝氏 15 ~ 25 度乾燥處所；如發生變質或過期，不可再食用。
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