3-[(2-chlorophenyl)methyl] -7-thia-3-azabicyclo[4.3.0] nona-8,10-diene

Absorption
Ticlopidine is rapidly absorbed with peak levels (T max ) occurring about 2 after dose. The drug is greater than 80% absorbed. Administration after meals results in a 20% increase in the AUC. Ticlopidine is 98% bound to plasma proteins.

Metabolism
Ticlopidine is metabolized extensively by the liver; only trace amounts are detected in urine.

Elimination
Ticlopidine t ½ is 4 to 5 days.

Special Populations
Hepatic Function Impairment

Average plasma concentration is slightly higher in cirrhosis.

Antacids
May reduce ticlopidine absorption.

Aspirin
Increased effect of aspirin on collagen-induced platelet aggregation.

Cimetidine
Elevated ticlopidine levels with possible increase in therapeutic and toxic effects.

Theophylline
Elevated serum theophylline concentrations, increasing risk of toxicity.

Phenytoin
Elevated phenytoin plasma levels with associated somnolence and lethargy have been reported. Exercise caution when administering with ticlopidine.

本品若同時併用丹參、當歸、川紅花、藏紅花併用，可能會增強抗凝血作用。

本品若同時併用吉林參、吉林參鬚、高麗參、西洋參併用，可能會降低抗凝血作用。