Absorption Readily absorbed from the GI tract. Bioavailability is 80% to 95%. T max is 1.99 h; C max is 7.12 mcg/mL.
Distribution Protein binding is 75% to 80%, primarily to albumin. Vd is approximately 0.4 L/kg.
Metabolism Actively concentrated by the thyroid. Metabolized rapidly in the liver; undergoes glucuronidation.
Elimination Urine (35%); less than 1% as unchanged. T ½ is 1 to 2 h. Total body clearance is approximately 7 L/h.
Peak Approximately 17 wk to normalize serum T 3 and T 4 concentrations.
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