6-piperidin-1-ylpyrimidine-2,4-diamine 3-oxide

Absorption
At least 90% is absorbed. T max is 1 h.

Distribution
0% is protein bound.

Metabolism
Approximately 90% is primarily metabolized by glucuronic acid conjugation.

Elimination
Primary route of excretion is urine. Mean t ½ is 4.2 h. Hemodialysis does not remove minoxidil or its metabolites.

Onset
Onset is 30 min.

Peak
Time to peak is 2 to 3 h.

Duration
Duration is approximately 75 h.

Guanethidine
May result in profound orthostatic hypotensive effects; discontinue guanethidine before minoxidil therapy.

Topical corticosteroids or retinoids, petrolatum
May enhance cutaneous drug absorption of topically applied minoxidil.