N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenyl-propanamide

本品的劑量宜根據患者年齡、體重、身體狀況、內在疾病、是否併用其它藥物、手術及麻醉種類而定。老年病人及虛弱病人的起始劑量宜降低。決定後續劑量時要將病人對起始劑量的反應列入考慮。

做為全身麻醉止痛輔助劑 : 低劑量 : 2μg/kg 本品低劑量最適合比較疼痛的小手術。中劑量 : 2-20μg/kg 當手術較複雜時則需要比較高的劑量，其作用時間則視劑量而定。高劑量 : 20-50μg/kg 在時間較長的大手術時，身體的壓力反應對於人體有害，用本品20-50μg/kg與笑氣／氧氣併用顯示能減輕以上的壓力反應，手術使用此範圍高劑量以後可能有手術後呼吸抑制的現象，因此在手術後便應注意呼吸並密切觀察。

做為麻醉劑 : 當減輕手術時的壓力反應非常重要時，可給予 50-100μg/kg ，並與氧氣及肌肉鬆弛劑併用。這種技術能提供麻醉作用而不需添加額外的麻醉劑。本品的這種使用法常被用於開心手術及其他需要保護心肌免受缺氧之苦的重要手術。

Amiodarone
Profound bradycardia, sinus arrest, and hypotension may occur.

Anesthesia (conduction, peridural, spinal)
When used with fentanyl, management of respiration may be complicated.

Diazepam
May produce CV depression when given with high doses of fentanyl.

Droperidol
May cause hypotension and decrease pulmonary arterial pressure.

MAOIs
Fentanyl not recommended for use in patients who have received MAOIs within 14 days.

Neuroleptics
Risk of hypertension may be increased. In addition, ECG monitoring is indicated.

Nitrous oxide
Nitrous oxide may cause CV depression with high-dose fentanyl.

Potent CYP3A4 inhibitors (eg, clarithromycin, diltiazem, erythromycin, ketoconazole, itraconazole, nefazodone, protease inhibitors [eg, ritonavir]), other CNS depressants (eg, alcohol, barbiturates, benzodiazepines, general anesthetics, other opioids, phenothiazines, sedating antihistamines, sedatives/hypnotics, skeletal muscle relaxants, tranquilizers)
Increased depressant effects; hypoventilation, hypotension, profound sedation, and life-threatening respiratory depression may occur.