Absorption
Bioavailability is approximately 95% and T max is approximately 30 min.

Distribution
Vd is approximately 0.12 L/kg (IV dose).

Metabolism
Metabolized by nonspecific enzymatic mechanisms in the liver.

Elimination
Cl is approximately 62 L/h (women) and 94 L/h (men). T ½ is 5 min (IV) and 1 h (subcutaneous). Excreted via the kidneys.

Onset
2 h (serum calcium concentrations begin to increase).

Peak
4 to 6 h (peak serum calcium concentrations).

Duration
16 to 24 h (serum calcium concentrations return to baseline).

Special Populations
Renal Function Impairment
In patients with severe renal function impairment (CrCl less than 30 mL/min), the AUC and t ½ increased 73% and 77%, respectively.

Gender
Systemic exposure is approximately 20% to 30% lower in men; no dosage adjustment needed.