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Distribution
40% protein bound.
Metabolism
Metabolized in the liver (N-dealkylation, hydroxylation, and glucuronidation).
Elimination
T ½ is approximately 50 h; approximately 10% is excreted in the urine as unchanged drug within 72 h and approximately 60% is excreted in the urine as metabolites.
Special Populations
Renal Function Impairment
Renal Cl decreased proportionally with Ccr and was approximately 50% lower in those with severe renal function impairment (Ccr less than 30 mL/min/1.73 m 2 ); however, this did not influence total body Cl.
Hepatic Function Impairment
Oral Cl was approximately 30% lower in those with stable hepatic cirrhosis but plasma concentrations were within normal range.
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