Absorption Steady-state peak and trough values range from 168 to 235 mcg/mL and 41 to 85 mcg/mL, respectively.
Distribution Vd is approximately 2 to 3 L/m 2 .
Elimination Mean t ½ is about 112 h.
Special Populations Gender
Women with colorectal cancer have a 25% lower intrinsic Cl than men; however, no changes in dosing are needed.
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