N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenyl-propanamide

本品的劑量隨病患狀況不同而異，在使用後應該定時評估。
成人：從未使用過類鴉片藥物者，應以最低劑量的fentanyl 25mcg/h為起始劑量。
兒童：本品只能用於對鴨片類藥物有耐受性的病童，該病童需正接受至少相當於45mg口服嗎啡的每日劑量。

Amiodarone
Profound bradycardia, sinus arrest, and hypotension may occur.

Anesthesia (conduction, peridural, spinal)
When used with fentanyl, management of respiration may be complicated.

Diazepam
May produce CV depression when given with high doses of fentanyl.

Droperidol
May cause hypotension and decrease pulmonary arterial pressure.

MAOIs
Fentanyl not recommended for use in patients who have received MAOIs within 14 days.

Neuroleptics
Risk of hypertension may be increased. In addition, ECG monitoring is indicated.

Nitrous oxide
Nitrous oxide may cause CV depression with high-dose fentanyl.

Potent CYP3A4 inhibitors (eg, clarithromycin, diltiazem, erythromycin, ketoconazole, itraconazole, nefazodone, protease inhibitors [eg, ritonavir]), other CNS depressants (eg, alcohol, barbiturates, benzodiazepines, general anesthetics, other opioids, phenothiazines, sedating antihistamines, sedatives/hypnotics, skeletal muscle relaxants, tranquilizers)
Increased depressant effects; hypoventilation, hypotension, profound sedation, and life-threatening respiratory depression may occur.