ACE inhibitors (eg, captopril), angiotensin II antagonists (eg, losartan) The antihypertensive effect may be decreased by sulindac.
Anticoagulants May increase effect of anticoagulants because of decreased plasma protein binding. May increase risk of gastric erosion and bleeding.
Aspirin Risk of GI adverse reactions may be increased; plasma levels of active sulindac metabolite may be reduced.
Bile acid sequestrants (eg, cholestyramine) Plasma levels of sulindac may be reduced.
Cimetidine Sulindac has increased cimetidine bioavailability.
Cyclosporine Risk of cyclosporine toxicity may be increased.
Diflunisal Plasma level of active sulindac metabolite may be reduced.
Dimethyl sulfoxide Dimethyl sulfoxide may decrease formation of active metabolite of sulindac, possibly resulting in decreased therapeutic effect. Also, topical dimethyl sulfoxide with sulindac has resulted in severe peripheral neuropathy.
Diuretics Decreased diuresis may result.
Lithium May decrease lithium clearance.
Methotrexate May increase methotrexate levels.
NSAIDs (eg, ibuprofen) Coadministration with other NSAIDs may increase the risk of GI toxicity.
Probenecid Sulindac plasma levels may be elevated.
Ranitidine Sulindac has increased ranitidine bioavailability.
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