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吸收：
Tramadol, Oral: Tmax, 1.8 hr
Tramadol, Bioavailability: (oral), 75%
Acetaminophen, Oral: Tmax, 0.9 hr
Acetaminophen, Bioavailability: (oral), 60% to 98%
Effect of food: (oral), delayed absorption
分佈：
Tramadol, Vd: 2.6 L/kg (males) and 2.9 L/kg (females)
Tramadol, Protein binding, 20%
Acetaminophen, Vd: 0.9 L/kg
Acetaminophen, Protein binding, 20%
代謝：
Tramadol- Hepatic; CYP2D6 and CYP3A4; extensively
Active metabolite: mono-O-desmethyltramadol (M1)
Acetaminophen-Hepatic; CYP2E1. CYP1A2 and CYP3A4
排泄：
Tramadol, Renal: 60% as metabolites and 30% as unchanged drug
Acetaminophen, Renal: less than 9% unchanged
Tramadol, Dialyzable: no (hemodialysis), less than 7% removed
Acetaminophen, Dialyzable: yes, although the procedure has not been shown to prevent or reduce liver damage following overdose
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