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Beta-adrenergic blockers
Increased lidocaine levels.
Cimetidine
Decreased lidocaine Cl.
Class I antiarrhythmic agents (eg, mexiletine, tocainide)
Toxic effects are additive and potentially synergistic.
Procainamide
Additive neurological and cardiac effects.
Succinylcholine
Prolongation of neuromuscular blockade.
Incompatibility
Amphotericin B, cephalosporins (parenteral), doxycycline, epinephrine, isoproterenol, methohexital, nitroprusside, norepinephrine, phenytoin, sodium bicarbonate, sulfadiazine.
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