8-Chloro-6-phenyl-4H-1,2,4-triazolo(4,3-a)-1,4-benzodiazepine

用量就患者病情、年齡、疾患之種類等增減之。
一般成人：就寢前一次口服1-2 mg。

Distribution
Plasma protein binding is 93%.

Metabolism
Extensively metabolized (4-hydroxy estazolam is the major metabolite).

Elimination
Metabolites primarily excreted in the urine with less than 5% of an administered dose excreted unchanged in the urine. Only 4% of the dose appears in the feces. Mean elimination t ½ varies from 10 to 24 h.

腳步笨拙或不穩、頭暈、昏昏欲睡、口齒不清、心灼熱、宿醉。

Alcohol, anticonvulsants, antihistamines, barbiturates, MAOIs, narcotics, phenothiazines, psychotropic drugs
May potentiate the CNS depressant effects of estazolam.

Azole antifungal agents (eg, ketoconazole), cimetidine, disulfiram, oral contraceptives, protease inhibitors (eg, indinavir)
Estazolam plasma levels may be elevated, increasing the pharmacologic and adverse effects.

Digoxin
May increase serum digoxin concentrations.

Rifamycins (eg, rifampin)
Estazolam plasma levels may be reduced, decreasing the pharmacologic effects.

Theophyllines
May antagonize sedative effects of estazolam.

重肌無力症患者、孕婦。
正在使用Ritonavir治療的患者。