CNS depressants (eg, hypnotics, sedatives, tranquilizers, antianxiety agents) Effects of these agents may be enhanced.
MAOIs(monoamine oxidase inhibitors) (eg, isocarboxazid) Hypertensive crisis may occur. Do not use in patients receiving MAOI therapy or within 14 days of stopping such treatment. May prolong and intensify the effects of chlorpheniramine.
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