2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide

Absorption
Rapid and consistent but incomplete; approximately 50% is absorbed from the GI tract. T max is 2 to 4 h.

Distribution
6% to 16% bound to plasma proteins.

Metabolism
Little or no metabolism by the liver.

Elimination
Approximately 50% is excreted unchanged in the feces. Approximately 50% is excreted in the urine within 24 h. T ½ is approximately 6 to 7 h.

Onset
1 h (oral).

Peak
2 to 4 h (oral).

Duration
24 h (oral). Duration of action is dose related.

Special Populations
Renal Function Impairment
Elimination is closely related to glomerular filtration rate. Significant accumulation occurs when CrCl falls below 35 mL/min/1.73 m² .

Aluminum salts, ampicillin, calcium salts
Plasma levels and pharmacologic effects may be decreased.

Clonidine
May add to or reverse antihypertensive effects; potentially life-threatening situations may occur, especially on withdrawal.

Diltiazem
Pharmacologic effects of atenolol may be increased; symptomatic bradycardia may occur.

Nifedipine, verapamil
Effects of both drugs may be increased.

NSAIDs
Some agents may impair antihypertensive effect.

Prazosin
May increase orthostatic hypotension.

Quinidine
Pharmacologic effects of atenolol may be increased.