Alcohol and other CNS depressants May cause increased CNS depression and may precipitate extrapyramidal reaction.
Anticholinergics May reduce therapeutic effects of and increase anticholinergic effects of chlorpromazine; may lead to tardive dyskinesia.
Barbiturate anesthetics May increase frequency and severity of neuromuscular excitation and hypotension.
Beta-blockers May result in increased plasma levels of beta-blocker and chlorpromazine.
Cisapride, sparfloxacin The risk of life-threatening cardiac arrhythmias, including torsades de pointes, may be increased.
Epinephrine, norepinephrine Actions of these drugs may be decreased or reversed.
Guanethidine The hypotensive effect of guanethidine may be inhibited.
Lithium May cause disorienting unconsciousness and extrapyramidal effects.
Meperidine May result in excessive sedation and hypotension.
Metrizamide Risk of seizure may increase.
Paroxetine Plasma levels of chlorpromazine may be elevated, increasing the risk of adverse reactions.
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