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Absorption
Hydralazine is rapidly absorbed. T max is 1 to 2 h and bioavailability is 30% to 50%.
Distribution
Hydralazine is 87% protein bound.
Metabolism
Hydralazine is subject to polymorphic acetylation and undergoes extensive hepatic metabolism.
Elimination
Hydralazine is excreted in urine mainly in the form of metabolites. The t ½ is 3 to 7 h.
Onset
Onset is 10 to 20 min (parenteral).
Duration
Duration is 6 to 12 h (oral) and 2 to 4 h (parenteral).
Special Populations
Slow acetylators
Slow acetylators generally have higher plasma levels of hydralazine and require lower doses to maintain control of BP.
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