Absorption T max is 2 to 4 h after dosing. Bioavailability is about 10% to 35%. Food decreases AUC about 40% and decreases C max about 50%.
Distribution Vd is about 17 L. Highly bound to albumin (about 95%).
Metabolism The major metabolite, valeryl 4-hydroxy valsartan, accounts for about 9% of the dose.
Elimination Half-life is about 6 h. Valsartan is primarily recovered in the feces (about 83%) and urine (about 13%). Recovery is mainly unchanged drug, with only about 20% of the dose recovered as metabolite. The plasma Cl is about 2 L/h.
Special Populations Renal Function Impairment No correlation between renal function and exposure to the drug.
Hepatic Function Impairment Patients with mild to moderate chronic liver disease have about twice the AUC value.
Elderly AUC is about 70% higher and t ½ is about 35% longer in elderly patients.
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