Anticoagulants Increased hypoprothrombinemic effect may occur.
Barbiturates, other enzyme inducers May increase the rate of active cyclophosphamide metabolite formation and possibly increase neutropenic effects.
Chloramphenicol, other enzyme inhibitors May inhibit cyclophosphamide's antineoplastic activity by decreasing rate of active metabolite formation.
Digoxin May cause decreased serum levels of digoxin.
Oral quinolone antibiotics May cause decreased GI absorption of quinolone antibiotics.
Succinylcholine and possibly mivacurium Prolongation of neuromuscular blockade by cyclophosphamide's inhibition of pseudocholinesterase may occur.
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