Alpha-adrenergic blockers (eg, phentolamine) Vasoconstricting and hypertensive effects are antagonized.
Diuretics Vascular response may be decreased.
General anesthetics (eg, halothane, cyclopropane), cardiac glycosides The potential for the myocardium to be sensitized to the effects of sympathomimetic amines is increased. Arrhythmias may result with coadministration and may respond to beta blockers.
Guanethidine May negate antihypertensive effects.
MAOIs Increases pressor response from vasopressors significantly; hypertensive crisis and intracranial hemorrhage are possible.
Rauwolfia alkaloids, methyldopa, furazolidone May result in hypertension.
Tricyclic antidepressants May potentiate pressor response.
Urinary acidifiers May increase elimination of ephedrine.
Urinary alkalinizers May decrease elimination of ephedrine.
Incompatibility Ephedrine is chemically incompatible with sodium bicarbonate; avoid admixture.
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