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Cardiac glycosides (eg, digoxin)
Administer magnesium sulfate with extreme caution because serious changes in cardiac conduction, which can result in heart block, may occur if administration of calcium is required to treat magnesium toxicity.
CNS depressants (eg, barbiturates, narcotics)
Possible additive CNS depressant effects.
Neuromuscular blocking agents
Potentiation of neuromuscular blockade.
Nitrofurantoin
Decreased absorption of nitrofurantoin (oral magnesium).
Penicillamine
Reduced penicillamine effects (oral magnesium).
Tetracyclines
Decreased absorption of tetracyclines (oral magnesium).
Incompatibility
Alcohol (in high concentrations), alkali carbonates and bicarbonates, alkali hydroxides, arsenates, barium, calcium, clindamycin phosphate, heavy metals, hydrocortisone sodium succinate, phosphates, polymyxin B sulfate, procaine hydrochloride, salicylates, streptomycin, strontium, tartrates, tetracycline, tobramycin.
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