1. Absorption
A) Bioavailability
1) Oral sodium bicarbonate results in gastric acid neutralization and carbon dioxide production. Sodium and excess bicarbonate are absorbed into the plasma (Reynolds, 1990).
2. Metabolism
A) Metabolism Sites and Kinetics
1) STOMACH
a) In the presence of stomach acid, bicarbonate ion forms carbon dioxide and water.
3. Excretion
A) Kidney
1) Plasma concentrations of bicarbonate are regulated by the kidney. In a normal healthy adult nearly all the glomerular filtered bicarbonate ion is reabsorbed with less than 1% excreted in the kidney. The excess bicarbonate, excreted in the urine along with sodium ions, causes the urine to become alkaline and has a diuretic effect (Reynolds, 1990).
|
|
Amphetamine, dextroamphetamine, ephedrine, flecainide, mecamylamine, methamphetamine, pseudoephedrine, quinidine
Sodium bicarbonate can decrease elimination of these drugs, thus increasing their therapeutic effects.
Chlorpropamide, lithium, methotrexate, salicylates, tetracyclines
Sodium bicarbonate can increase elimination of these drugs, thus decreasing their therapeutic effect.
Ketoconazole
PO sodium bicarbonate may decrease the dissolution of ketoconazole in the GI tract, reducing the effectiveness.
|
