(E)-14,17,26,32-tetrabutyl-5-ethyl-8-(1-hydroxy-2-methylhex-4-enyl)-1,3,9,12,15,18,20,23,27-nonamethyl-11,29-dipropyl-1,3,6,9,12,15,18,21,24,27,30-undecaazacyclodotriacontan-2,4,7,10,13,16,19,22,25,28,31-undecaone
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Allopurinol, amiodarone, beta-blockers (eg, carvedilol), bromocriptine, colchicine, danazol, diltiazem, fluconazole, grapefruit and grapefruit juice, imipenem-cilastatin, itraconazole, ketoconazole, macrolide antibiotics (eg, erythromycin), metoclopramide, nefazodone, nicardipine, protease inhibitors (eg, indinavir, nelfinavir, ritonavir, saquinavir), quinupristin/dalfopristin, serotonin reuptake inhibitors (eg, fluoxetine, sertraline), verapamil May increase cyclosporine concentrations.
Aminoglycosides, amphotericin B, cimetidine, colchicine, NSAIDs, ranitidine, tacrolimus, trimethoprim-sulfamethoxazole, melphalan, quinolones Additive nephrotoxicity possible.
Azathioprine, corticosteroids, cyclophosphamide, verapamil May cause additive immunosuppression, increasing risk of infection and malignancy.
Carbamazepine, hydantoins, nafcillin, octreotide, orlistat, phenobarbital, rifampin, rifabutin, St. John's wort, terbinafine, ticlopidine May decrease cyclosporine effects.
Digoxin, methotrexate, sirolimus Plasma levels of these agents may be elevated by cyclosporine.
Etoposide May increase etoposide concentrations.
Live vaccines Vaccination may be less effective.
Metoclopramide Increases absorption of cyclosporine.
Potassium-sparing diuretics Causes hyperkalemic effects; avoid concomitant use.
Statins (eg, lovastatin) May cause severe myopathy or rhabdomyolysis; avoid concurrent use.
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