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Aspirin
Short-term (up to 4 days) coadministration of aspirin with cilostazol showed a 22% to 37% increase in inhibition of adenosine diphosphate–induced ex vivo platelet aggregation compared with aspirin alone.
Moderate inhibitors of CYP3A4 (eg, clarithromycin, diltiazem, erythromycin, grapefruit juice)
Cilostazol plasma concentrations may be elevated, increasing the pharmacologic and adverse reactions.
Omeprazole
Coadministration of omeprazole did not significantly affect the metabolism of cilostazol, but the systemic exposure to 3,4-dehydro-cilostazol was increased 69%.
CYP-450 system
Cilostazol could have pharmacokinetic interactions because of effects of other drugs on its metabolism by CYP3A4 or CYP2C19.
Platelet function inhibitors
Cilostazol could have pharmacodynamic interactions with other platelet function inhibitors.
Strong inhibitors of CYP3A4 (eg, fluoxetine, fluvoxamine, itraconazole, ketoconazole, nefazodone)
Cilostazol plasma concentrations may be elevated, increasing the pharmacologic and adverse reactions.
本品若同時併用丹參、當歸、川紅花、藏紅花併用，可能會增強抗凝血作用。
本品若同時併用吉林參、吉林參鬚、高麗參、西洋參併用，可能會降低抗凝血作用。
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