Absorption Rapidly absorbed 15 to 30 min following IV triphasic serum decay pattern.
Distribution Undergoes rapid distribution (from blood to tissue) and extensive tissue binding.
Metabolism Metabolized by the hepatic P450 3A cytochromes. The metabolite, deacetyl vinblastine, is more active than parent drug.
Elimination Major route of excretion is the biliary system (liver). Terminal t ½ is 24.8 h.
Special Populations Hepatic Function Impairment
Toxicity may be enhanced. A dose reduction is recommended. In patients with a direct serum bilirubin value more than 3 mg/dL, a 50% dose reduction is recommended.
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