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Absorption
Topical steroids can be absorbed from intact skin. Occlusive dressings, inflammation, and other disease processes in the skin increase percutaneous absorption of topical steroids.
Distribution
Once absorbed, corticosteroids are variably bound to plasma protein.
Metabolism
Corticosteroids are metabolized primarily in the liver.
Elimination
Corticosteroids are excreted primarily by the kidneys and to varying amounts into the bile.
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