Absorption T max for the 3.6 mg implant is 12 to 15 days in men and 8 to 22 days in women. T max for the 10.8 mg implant is 2 h in men. C max for the 3.6 mg implant is about 1.46 ng/mL in women and 2.84 ng/mL in men and for the 10.8 mg is about 8 ng/mL in men.
Distribution Vd is 44.1 L in men and 20.3 L in women. Protein binding is 27%.
Metabolism Hydrolysis of the C-terminal amino acids.
Elimination The t 1/ 2 for the 3.6 mg implant is 4.2 h in men and 2.3 h in women. More than 90% is excreted in urine, 20% unchanged. Mean systemic Cl for the 3.6 mg implant is 111 mL/min in men and to 164 mL/min in women.
Onset 1 wk.
Peak 2 to 4 wk.
Special Populations Renal Function Impairment In CrCl less than 20 mL/min, the t 1/ 2 is 12.1 h.
Increased body weight A decline in AUC of about 1% to 2.5% was observed with a kg increase in body weight.
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