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Amphetamine, dextroamphetamine, ephedrine, flecainide, mecamylamine, methamphetamine, pseudoephedrine, quinidine
Sodium bicarbonate can decrease elimination of these drugs, thus increasing their therapeutic effects.
Chlorpropamide, lithium, methotrexate, salicylates, tetracyclines
Sodium bicarbonate can increase elimination of these drugs, thus decreasing their therapeutic effect.
Ketoconazole
PO sodium bicarbonate may decrease the dissolution of ketoconazole in the GI tract, reducing the effectiveness.
Incompatibility
Do not mix with IV solutions containing catecholamines, such as dobutamine, dopamine, and norepinephrine.
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