光田綜合醫院

西藥品查詢

外觀圖示：

外觀描述：

白色橢圓形錠劑，一面有STD字樣，另一面有293字樣。

醫令代碼：

23139

商品名：

levoZINe 5MG

中文名：

舒敏寧膜衣錠

學名：

Levocetirizine

劑型：

TAB

孕婦用藥分級：

B 級

健保碼：

AC49833100

藥品許可證：

衛署藥製字第049833號

仿單下載：

201105191421505334.pdf

用藥指導單張：

ATC7藥理類別：

R RESPIRATORY SYSTEM

R06 ANTIHISTAMINES FOR SYSTEMIC USE

R06A ANTIHISTAMINES FOR SYSTEMIC USE

R06AE Piperazine derivatives

R06AE09 levocetirizine

結構式：

2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid

UpToDate：

UpToDate連結

藥理作用：

Levocetirizine, an enantiomer of cetirizine, is an antihistamine that selectively inhibits the effect of H(1)-receptors .

適應症：

治療成人及六歲以上孩童因過敏性鼻炎、慢性蕁麻疹等所引起的各種過敏徵狀。

用法用量：

1. 成人及十二歲以上青少年：建議每日劑量為5mg。
2. 老年患者：具有中度到嚴重腎功能障礙的老年患者，需調整其劑量。
3. 六歲至十二歲孩童：建議每日劑量為5mg。
4. 六歲以下孩童尚不建議使用。

副作用：

頭痛、嗜睡、口乾、疲勞。

藥物動力學：

Absorption

Rapidly and extensively absorbed. T _max is 0.9 h. C _max is 270 and 308 ng/mL after single and repeated once-daily dosing, respectively. Steady state achieved after 2 days. Food delayed T _max by approximately 1.25 h and decreased C _max by approximately 36%.

Distribution

Plasma protein binding is approximately 92%. Vd is approximately 0.4 L/kg.

Metabolism

Metabolism is less than 14% and by aromatic oxidation, N- and O-dealkylation, and taurine conjugation.

Elimination

The half-life is about 8 to 9 h. Elimination is 85.4% and 12.9% via urine and feces, respectively. Excreted both by glomerular filtration and active tubular secretion.

交互作用：

No formal in vivo drug-drug interaction studies have been performed with levocetirizine. Drug interaction studies have been performed with racemic cetirizine.

Alcohol, CNS depressants

Additive CNS depressant effects; concurrent use should be avoided.

Food

Food had no effect on the extent of levocetirizine exposure; however, the half-life was delayed about 1.25 hours and the C _max was decreased about 36% after administration with a high-fat meal. Levocetirizine may be taken without regard to food.

Ritonavir

Cetirizine AUC and half-life may be increased, while Cl may be decreased. The risk of adverse reactions may be increased.

Theophylline

May decrease cetirizine Cl.

禁忌：

1. 對Levocetirizine過敏，或對本藥中任何成分過敏，亦或對piperazine衍生物過敏的患者，應避免使用本藥。
2. 嚴重腎功能障礙者（creatinine clearance < 10 ml/min）禁用。

注意事項：

若對galactose無耐受力，或Lapp lactase缺乏，或有glucose-galactose吸收障礙等遺傳疾病者，不應使用本藥。

過量處理：

症狀：若服用過量時，成人會有嗜睡的現象，孩童則會先興奮不安，而後伴隨睏倦。
對於levocetirizine過量並無特殊的解毒劑。建議以徵狀治療。以可考慮洗胃（服用短期內）。血液透析對levocetirizine的排除無效。

藥品保存方式：

25℃以下儲存。