外觀描述：

棕灰色圓扁形錠劑,8mm,CH 11

醫令代碼：

23173

商品名：

ergoCAFE(偏頭痛) 1MG

中文名：

痛安錠

學名：

Ergotamine 1mg, Caffeine 100mg

劑型：

TAB

孕婦用藥分級：

X 級

健保碼：

AC19210100

藥品許可證：

衛署藥製字第019210號

仿單下載：

用藥指導單張：

ATC7藥理類別：

結構式 ：

UpToDate：

藥理作用 ：

Ergotamine tartrate對顱外動脈脹大具有特殊之血管緊張作用，功能消退偏頭痛發作及其他血管性頭痛症，咖啡因caffeine功能加速及增進麥角胺Ergotamine tartrate在腸內吸收。

適應症：

血管性頭痛如：偏頭痛、組織胺性頭痛。

用法用量：

一有發作先兆，應即用Ergocafe
首次療法：
初次量:Ergocafe兩錠，在半小時內仍未見效時，應再服一錠，必要時每隔半小時可照量服用一次。
小孩(6-12歲)：初次量Ergocafe一錠，以前次發作所需總量為根據，開始劑量可能增至三錠，必要時每半小時可再用藥一次，以下列最高劑量為限：
每次發作及每日最高劑量：
成人：Ergotamine tartrate 6mg，相當於6錠之Ergocafe
小孩：Ergotamine tartrate 3mg，相當於3錠之Ergocafe
每星期最高劑量：
成人：Ergotamine tartrate 10mg，相當於10錠之Ergocafe
小孩：Ergotamine tartrate 5mg,相當於5錠之Ergocafe

副作用：

神經過敏之病者或未經醫師指導而延長治療後，可能發生噁心及嘔吐，感覺異常，四肢疼痛及虛弱。

藥物動力學：

Ergotamine：
Absorption
Poorly absorbed following GI and SL administration.

Metabolism
Metabolized by the liver.

Elimination
T ½ is approximately 2 h; 90% of metabolites are excreted in the bile. Unmetabolized ergotamine is erratically excreted in the saliva and trace amounts are excreted in the feces and urine.

Caffeine：
Absorption
99% absorbed orally. C max is 5 to 25 mcg/mL; T max is 15 to 120 min.

Distribution
Rapidly distributed throughout tissues; crosses the blood-brain barrier and placenta; excreted in breast milk. 17% to 36% protein bound. Vd is 0.64 kg.

Metabolism
Rapidly metabolized in the liver to 1-methyluric acid, 1-methylxanthine, and 7-methylxanthine; CYP1A2 is involved in the biotransformation.

Elimination
The t ½ is 3 to 5 h. Approximately 1% is excreted in the urine as unchanged drug.

Special Populations
Pregnancy, smoking, and cirrhosis
The t ½ is increased.

交互作用：

CYP 3A4 Inhibitors (e.g. Macrolide Antibiotics and Protease Inhibitors)
Ergotamine tartrate and caffeine should not be administered with other vasoconstrictors. Use with sympathominetics (pressor agents) may cause extreme elevation of blood pressure.
The beta-blocker Inderal (propranolol) has been reported to potentiate the vasoconstrictive action of ergotamine tartrate and caffeine by blocking the vasodilating property of epinephrine.
Nicotine may provoke vasoconstriction in some patients, predisposing to a greater ischemic response to ergot therapy.
The blood levels of ergotamine-containing drugs are reported to be elevated by the concomitant administration of macrolide antibiotics and vasospastic reactions have been reported with therapeutic doses of the ergotamine-containing drugs when coadministered with those antibiotics.

禁忌：

凡有周圍性血管病、管腔閉合性血管病、冠狀動脈性心病、嚴重性高血壓、肝腎機能不全、妊娠期及授乳期、膿毒性症狀等。

注意事項：

如見有手指或足趾刺痛之徵狀，應立即停止用藥，並向醫師就診。

藥品保存方式：

藥品應置於攝氏 15 ~ 25 度乾燥處所；如發生變質或過期，不可再食用。